![]() There are, however, many barriers to adherence, 1,2 with cost being a key driver of adherence problems. 1,2 Such adherence is highly important to achieve the clinical benefits of prescription medicines. Across clinical conditions and populations, approximately half of patients do not adhere to their prescribed treatments. 1 However, many people struggle to take their medications as prescribed. Lack of long-term outcomes and uncertainty around program sustainment from co-pay assistance programs are limitations.Ĭonclusions: Limited evidence suggests a potential link between co-pay assistance and clinical outcomes future research addressing study design challenges in measuring the effects of co-pay assistance is needed.Īlmost half the individuals in the United States are prescribed medicine and nearly a quarter take 3 or more medications. Co-pay assistance was associated with improved treatment persistence/adherence across various diseases, with limited indirect evidence of this translating into clinical outcomes improvements. One article assessed the association between co-pay assistance and patient-reported outcomes, 7 explored the relationship between co-pay assistance and clinical outcomes, and 6 assessed the impact of policy/program changes on co-pay assistance. Most studies were retrospective claims analyses (n = 10) there was also 1 randomized controlled trial and 1 prospective and observational study. Results: A total of 1249 initial articles were identified, of which 19 published articles representing 12 studies were included. Articles from the United States published between January 2015 and June 2021 were included. Methods: The population of interest was patients who had received co-pay assistance the intervention was co-pay assistance comparator was no co-pay assistance and outcomes were treatment adherence, compliance, discontinuation, interruption, barriers to adherence, and specific therapeutic outcomes. Study Design: A literature review was conducted by searching Embase and MEDLINE. A literature review to identify peer-reviewed articles on studies evaluating the impact of co-pay assistance on clinical, patient, and economic outcomes was conducted. Objectives: Patient assistance programs (eg, co-pay assistance) may reduce patients’ out-of-pocket costs for prescription medicines, providing financial assistance to access medicines for reduced or no cost. ![]()
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